The following information applies to the use of perchloroethylene (PCE) in research labs. If you work at the University of Iowa and have questions about using PCE in areas other than a laboratory, please contact the EHS Industrial Hygienist.  

Perchloroethylene (127-18-4), also known as tetrachloroethylene, tetrachloroethene, perc and PCE, is a colorless liquid with a mild, chloroform-like odor used in both laboratory and workshop settings. PCE can cause damage to the central nervous system, liver damage, kidney effects, immune and hematologic effects, and development and reproduction. PCE can also cause several types of cancer including bladder cancer, non-Hodgkin lymphoma, and multiple myeloma. 

 

Because of the risk associated with PCE the EPA, under the Toxic Substance Control Act (TSCA) issued a regulation for the manufacturing and use of PCE. Including specific requirements for the use of PCE in labs.  

The EPA Risk Management Rule for PCE requires people using PCE in a lab to do the following: 

  • Use in a fume hood or glove box at all times. 

  • Use dermal protection that is impervious to PCE.  Disposable latex and nitrile gloves are not impervious to PCE. 

  • Document and keep records of: 

    • Who potential exposed people are and what dermal PPE they are using (This will be documented through the site-specific training form). 

    • Any occurrence of direct dermal contact with PCE. (This will done through the First Report of Injury Form).  

 

Questions about this topic can be directed here. 

 

Documents:  

Training: 

Perchloroethylene Safety for Labs- W557OS (coming soon)

  • This course is required initially for all people using perchloroethylene and covers the items required by the EPA regulations.

  • Audience: Persons using perchloroethylene.

     

External Links: