Methylene Chloride


Methylene chloride is used as a solvent in paint strippers, as a propellant in aerosols, in the manufacture of photographic film, and as a process solvent in the manufacturing of drugs. In the research laboratory it is commonly used for extractions. It is also used as a metal cleaning and finishing solvent. The National Institute for Occupational Health and Safety (NIOSH) and the Occupational Safety and Health Administration (OSHA) recommend that methylene chloride be regarded as a "potential occupational carcinogen" and that occupational exposures be controlled.

What is Methylene Chloride?

 Methylene chloride (CH2Cl2) is a colorless, liquid with a mild, sweet ether-like odor, that evaporates very quickly and will not easily burn. It is also known as methylene dichloride dichloromethane, DCM, methylene bichloride and methane dichloride. Background levels of methylene chloride in air are usually less than 1 part per billion (ppb).

Can methylene chloride affect my health?


Because methylene chloride is a volatile liquid, exposure can occur through inhalation. Exposure to methylene chloride may result in interference with the delivery of oxygen to tissues and central nervous system impairment depending upon its concentration in air. If you breathe methylene chloride at concentrations of 300 parts per million (ppm) or greater for a short period of time (3-4 hours) you may not be able to hear faint sounds and your vision may be slightly impaired. If you breathe in larger amounts (800 ppm) your ability to react fast, remain steady or perform tasks that require precise hand movements may be impaired. Additionally, prolonged exposures can produce headaches, irritability, dizziness, and nausea, tingling in the arms and legs, and numbness in the fingers and toes. In most cases, these effects will stop shortly after the exposure ends. The odor threshold varies from individual to individual, but concentrations of 200-300 ppm are usually easily detected by most persons. However, do not relay on your sense of smell to help you avoid unwanted exposures!

Direct Contact – 

If not removed promptly, methylene chloride causes intense burning through direct skin contact and can cause corneal burns through direct eye contact. Prolonged skin contact may result in dermatitis. Inhalation of vapors may cause severe irritation of the respiratory system. Ingestion may cause nausea, vomiting, gastrointestinal irritation and burns to the mouth and throat. Methylene chloride is a poison and may be fatal if swallowed.

Other Hazards – 

Closed containers exposed to heat may explode. Methylene chloride is incompatible with alkali metals, strong oxidizing agents, strong bases, and oxides of nitrogen, zinc, aluminum, water, magnesium, and amines.

Current Exposure Limit Information

Agency 8-Hour Exposure Limit 15-Minute Exposure Limit
OSHA 25 ppm 125 ppm
ACGIH 50 ppm  
NIOSH Lowest Feasible Concentration  

Guidelines for Minimizing Worker Exposure 

  • Employ effective engineering controls, good work practices and proper maintenance procedures. 
  • Ideally, all work with methylene chloride should be conducted in a chemical fume hood (that has been tested by the EHS within the last 12 months) or in another type of appropriate exhaust ventilation. Using enclosed processes may also control exposure. 
  • Provide appropriate personal protective equipment (PPE) such as safety glasses with side shields, splash-proof goggles, and/or chemical-resistant aprons, coveralls, lab coats and gloves. 
  • Require that workers change any clothing that becomes contaminated with methylene chloride. 
  • Eating, drinking, smoking and the storage of food should be prohibited in areas where methylene chloride is stored or used.
  • Exposures that cannot be controlled with ventilation or other work practices may require the use of a respirator. 
  • When possible, replace methylene chloride with a chemical that has been shown not to cause cancer or other adverse health effects in animals or humans. 
  • It is recommended that workers who are or who may be exposed to methylene chloride be given a copy of this fact sheet. 
  • Immediately and thoroughly wash with soap and water all areas of the body that come into contact with methylene chloride. Know the location and proper operation of safety showers in your immediate work area. 

 Medical Treatment and Surveillance


  • Life threatening injuries should be treated as soon as possible at the nearest medical facility.
  • For emergency injuries or illness use the UIHC Emergency Treatment Center.  Inform them that the incident is work related.
  • For other workplace injuries and illnesses use the UI HealthWorks (319-665-2111) which is located on Highway 965 in North Liberty.

Surveillance and Consultation 

Under OSHA's Laboratory Standard employees may receive a medical consultation, examination, and surveillance if needed, regarding potential exposures in the laboratory setting.  For more information contact UI HealthWorks (319-356-3335).

Spill Response

  • Areas that handle hazardous chemicals or chemical products must be prepared to handle simple chemical spills. This is an OSHA requirement. Clean up and containment costs incurred are the responsibility of the department.
  • A simple spill can be absorbed or otherwise managed by the user of the chemical. Contact EHS at 335-8501 for guidance and assistance. The University does not provide chemical spill cleanup services.
  • Spill kit supplies are available from Biochemistry Stores at 335-7927 or Chemistry Stores at 335-1378.
  • A major spill (one that spreads rapidly, presents an inhalation hazard, endangers people or the environment, and/or involves personal injury or rescue) is handled as an emergency by the Department of Public Safety, city Fire Departments, and the Johnson County HazMat Team.
     In the event of a major spill, call 911.

Waste Disposal Guidelines

  • Methylene chloride waste is handled as a hazardous waste. Refer to EHS’ "Waste Management Guidelines and Procedures Manual" regarding the collection, storage, and disposal of hazardous wastes.
  • Methylene chloride should be collected with other halogenated solvents, and should not be commingled with other types of hazardous waste.

For Assistance in:


  • Lab Areas
Rick Byrum, 335-7964
  • Facility Shops and Other Non Laboratory Areas
Justin Newnum, 335-9554
  • UIHC
UIHC Safety and Security Office, 356-2658


  • DHHS (NIOSH) Publication No 86-114

  • OSHA Safety and Health Topics – Methylene Chloride.