9.1.2 Responsibilities of the PI

In order to insure safety in research activities, ultimate responsibility rests with the PI, which includes:

  • Initiating or modifying rDNA research subject to the NIH Guidelines only after that research or the modification has been approved by the IBC.
  • Following appropriate procedures regarding the classification of the experiment.
  • Reporting within 30 days to the BSO, IBC and NIH/ OBA (Office of Biotechnology Activities) all significant problems with and violations of the NIH Guidelines and all significant research-related accidents and illnesses.
  • Being adequately trained in good microbiological techniques.
  • Petitioning NIH/OBA for determination of containment for experiments requiring a case-by-case review and for experiments not covered by the NIH Guidelines.
  • Reporting new information bearing on the NIH Guidelines to the NIH/OBA and IBC.
  • Registering all rDNA research with the IBC. 
  • Submitting any subsequent changes to the research protocol to the IBC for review and approval or disapproval.
  • Remaining in communication with the IBC throughout the conduct of the project.
  • Making protocols available that describe the potential biohazards and precautions to be taken.
  • Informing his/her staff of the reasons and provisions for any precautionary medical practices.
  • Supervising the safety performance of his/her staff and correct work errors and conditions that may result in the release of rDNA materials.
  • Instructing and training laboratory staff in:
  1. Practices and techniques required to ensure safety, and
  2. Protocols for dealing with accidents.