These guidelines describe three combinations of practices, safety equipment and facilities for experiments on animals infected with agents that produce or may produce human infection. They provide increasing levels of protection to personnel and the environment and are recommended as minimal standards for activities involving infected laboratory mammals. These three combinations are designated in each of the ABSL (Animal Biosafety Levels) 1 through 3 and describe animal facilities and practices applicable to work on animals infected with agents assigned to corresponding BSL1 through 3.
The reference for this section is the BMBL, 5th Edition, 2007, U.S. Department of Health and Human Services. See Appendix Q of the NIH Guidelines for additional requirements specific to large animals involved in research with rDNA.