The purpose of PPE is to act as a barrier to minimize the risk of exposure to aerosols, splashes and accidental inoculation. Exposure may occur via apparent or unapparent skin lesions or through the membranes of the eye, nose or mouth. PPE is often used in combination with BSCs and other equipment that contain the agents or animals being handled. PPE should be worn only while working in the laboratory; all PPE should be removed and hands should be washed before exiting the laboratory. Examples of PPE and the protection afforded are listed below in Table 2.